{"paper":{"title":"An analytical model for gold nanoparticle radiosensitisation","license":"http://creativecommons.org/licenses/by-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Pedro Teles","submitted_at":"2025-06-07T05:28:46Z","abstract_excerpt":"In this paper, we derive a variance-driven Local-Effect-Model ($\\sigma$-LEM) to predict radiosensitization due to gold nanoparticles (AuNP). Assuming that the number of Au photo-ionisations scales strictly with particle volume $V_{\\mathrm{NP}}\\propto R^{3}$, a linear relation between dose-enhancement ratio and concentration is achieved ($DER = 1 + K_c,c$), in which $K_c$ is a beam-quality and nucleus-size-specific term, and $c$ is the concentration in mM. Furthermore, assuming that the cascade energy deposition is log-normally distributed, the enhanced dose in each target voxel can be written "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.06671","kind":"arxiv","version":7},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2506.06671/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}