{"paper":{"title":"Rate-Independent Epigenetics: a thermodynamically consistent framework for modelling epigenetic response","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"Ignacio Romero, Jacobo Ayensa-Jim\\'enez","submitted_at":"2026-07-16T07:30:36Z","abstract_excerpt":"Epigenetic changes -- heritable, long-lived, yet actively reversible modifications of the chromatin state -- display memory, threshold activation and hysteresis, features that are the hallmark of rate-independent dissipative evolution. We propose a mathematical framework, Rate-Independent Epigenetics, that models epigenetic change within the theory of rate-independent systems and is consistent with two fundamental principles identified with the laws of thermodynamics. In this framework, a model is specified by a state space of epigenetic configurations, a stored-energy functional depending on "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.14664","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2607.14664/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}