{"paper":{"title":"The molecular clock of neutral evolution can be accelerated or slowed by asymmetric spatial structure","license":"http://creativecommons.org/licenses/by/3.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Benjamin Allen, Christine Sample, Christopher Paoletti, Martin A. Nowak, Ruben C. Medeiros, Yulia A. Dementieva","submitted_at":"2014-09-18T20:39:03Z","abstract_excerpt":"Over time, a population acquires neutral genetic substitutions as a consequence of random drift. A famous result in population genetics asserts that the rate, $K$, at which these substitutions accumulate in the population coincides with the mutation rate, $u$, at which they arise in individuals: $K=u$. This identity enables genetic sequence data to be used as a \"molecular clock\" to estimate the timing of evolutionary events. While the molecular clock is known to be perturbed by selection, it is thought that $K=u$ holds very generally for neutral evolution. Here we show that asymmetric spatial "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1409.5459","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}