{"paper":{"title":"Force-dependent switch in protein unfolding pathways and transition state movements","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"cond-mat.soft","authors_text":"D. Thirumalai, Michael Hinczewski, Pavel I. Zhuravlev, Shaon Chakrabarti, Susan Marqusee","submitted_at":"2015-12-28T17:57:00Z","abstract_excerpt":"Although known that single domain proteins fold and unfold by parallel pathways, demonstration of this expectation has been difficult to establish in experiments. Unfolding rate, $k_\\mathrm{u}(f)$, as a function of force $f$, obtained in single molecule pulling experiments on src SH3 domain, exhibits upward curvature on a $\\log k_\\mathrm{u}(f)$ plot. Similar observations were reported for other proteins for the unfolding rate $k_\\mathrm{u}([C])$. These findings imply unfolding in these single domain proteins involves a switch in the pathway as $f$ or $[C]$ is increased from a low to a high val"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.08470","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}