{"paper":{"title":"Cu2+ Affects Amyloid-\\b{eta} (1-42) Aggregation by Increasing Peptide-Peptide Binding Forces","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"Francis Hane, Gary Tran, Simon Attwood, Zoya Leonenko","submitted_at":"2017-04-26T19:37:04Z","abstract_excerpt":"The link between metals, Alzheimers disease (AD) and its implicated protein, amyloid \\b{eta} (A\\b{eta}), is complex and highly studied. AD is believed to occur as a result of the misfolding and aggregation of A\\b{eta}. The dyshomeostasis of metal ions and their propensity to interact with A\\b{eta} has also been implicated in AD. In this work, we use single molecule atomic force spectroscopy to measure the rupture force required to dissociate two A\\b{eta} (1 42) peptides in the presence of copper ions, Cu2+. In addition, we use atomic force microscopy to resolve the aggregation of A\\b{eta} form"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1704.08317","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}