{"paper":{"title":"Bayesian Manifold-Constrained-Prior Model for an Experiment to Locate Xce","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN","q-bio.QM"],"primary_cat":"stat.AP","authors_text":"Alan B. Lenarcic, Fernando Pardo-Manuel de Villena, John D. Calaway, William Valdar","submitted_at":"2018-12-20T21:49:00Z","abstract_excerpt":"We propose an analysis for a novel experiment intended to locate the genetic locus Xce (X-chromosome controlling element), which biases the stochastic process of X-inactivation in the mouse. X-inactivation bias is a phenomenon where cells in the embryo randomly choose one parental chromosome to inactivate, but show an average bias towards one parental strain. Measurement of allele-specific gene-expression through pyrosequencing was conducted on mouse crosses of an uncharacterized parent with known carriers. Our Bayesian analysis is suitable for this adaptive experimental design, accounting for"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.08863","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}