{"paper":{"title":"Accuracy versus Predominance: Reassessing the validity of the quasi-steady-state approximation","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["math.DS","q-bio.QM"],"primary_cat":"physics.chem-ph","authors_text":"Justin Eilertsen, Kashvi Srivastava, Santiago Schnell, Victoria Booth","submitted_at":"2025-01-11T02:06:51Z","abstract_excerpt":"The application of the standard quasi-steady-state approximation to the Michaelis--Menten reaction mechanism is a textbook example of biochemical model reduction, derived using singular perturbation theory. However, determining the specific biochemical conditions that dictate the validity of the standard quasi-steady-state approximation remains a challenging endeavor. Emerging research suggests that the accuracy of the standard quasi-steady-state approximation improves as the ratio of the initial enzyme concentration, $e_0$, to the Michaelis constant, $K_M$, decreases. In this work, we examine"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2501.06406","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2501.06406/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}