{"paper":{"title":"Delay-constrained re-entry governs large-scale brain seizures and other network pathologies","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Fabrice Bartolomei, Huifang E. Wang, Marmaduke Woodman, Maxime Guye, Paul Triebkorn, Viktor Jirsa","submitted_at":"2025-08-06T19:07:39Z","abstract_excerpt":"Re-entry of travelling excitation loops is a long-suspected driver of human seizures, yet how such loops arise in patient brain networks -- and how susceptible they are to targeted disruption -- remains unclear. We reconstruct a millimetre-scale virtual brain from diffusion MRI of a drug-resistant epilepsy patient, embed excitable Epileptor neural fields, and show that realistic cortico-cortical delays are sufficient to generate self-sustaining re-entry. Systematic parameter sweeps reveal a narrow delay-coupling window that predicts oscillation frequency and seizure duration across 184 recorde"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.04824","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2508.04824/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}