{"paper":{"title":"CaMKII activation supports reward-based neural network optimization through Hamiltonian sampling","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.NC"],"primary_cat":"cs.NE","authors_text":"David Kappel, Feng Chen, Robert Legenstein, Sen Song, Wolfgang Maass, Zhaofei Yu","submitted_at":"2016-06-01T08:12:34Z","abstract_excerpt":"Synaptic plasticity is implemented and controlled through over thousand different types of molecules in the postsynaptic density and presynaptic boutons that assume a staggering array of different states through phosporylation and other mechanisms. One of the most prominent molecule in the postsynaptic density is CaMKII, that is described in molecular biology as a \"memory molecule\" that can integrate through auto-phosporylation Ca-influx signals on a relatively large time scale of dozens of seconds. The functional impact of this memory mechanism is largely unknown. We show that the experimenta"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1606.00157","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}