{"paper":{"title":"Landmarking with Latent Class Mixed Models for Dynamic Prediction of Time-to-event Data with Heterogeneous Biomarker Trajectories","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Catalina A. Vallejos, Charlie W. Lees, Nathan Constantine-Cooke, V\\'ictor Velasco-Pardo","submitted_at":"2026-06-23T15:09:19Z","abstract_excerpt":"The increasing ability to securely access electronic health records (EHR) has created unprecedented opportunities to monitor the health trajectories of large heterogeneous patient populations throughout their lifetime. Repeated measurements of time-varying covariates (such as biomarkers measured via routine blood tests) can inform dynamic risk prediction of time-to-event outcomes, updating risk estimates as new information becomes available. Existing dynamic risk prediction approaches often assume homogeneous longitudinal trajectories across individuals. This assumption is not met when there i"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.24678","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.24678/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}