{"paper":{"title":"A Voxel-Wise Uncertainty-Guided Framework for Glioma Segmentation Using Spherical Projection-Based U-Net and Localized Refinement in Multi-Parametric MRI","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Chen Yang, Chunhao Wang, Fang-Fang Yin, Minbin Chen, Rihui Zhang, Zhenyu Yang","submitted_at":"2025-07-21T13:46:26Z","abstract_excerpt":"Purpose: Accurate segmentation of glioma subregions in multi-parametric MRI (MP-MRI) is essential for diagnosis and treatment planning but remains challenging due to tumor heterogeneity and ambiguous boundaries. This study proposes an uncertainty-guided hybrid framework integrating spherical projection-based 2D modeling with targeted 3D refinement to enhance segmentation accuracy and interpretability. Methods: Using the BraTS2020 dataset (369 patients, four-modality MP-MRI), three 2D U-Nets were trained to segment enhancing tumor (ET), tumor core (TC), and whole tumor (WT). Voxel-wise uncertai"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2507.15622","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2507.15622/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}