{"paper":{"title":"High-Contrast Interferometric Imaging of Single-Molecule Dynamics on Optical Fibers","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["physics.app-ph","physics.bio-ph"],"primary_cat":"physics.optics","authors_text":"Chaoyang Gong, Guifeng Li","submitted_at":"2025-10-11T06:55:43Z","abstract_excerpt":"Single-molecule detection enables direct observation of individual biomolecular events, providing mechanistic insights into biological processes and offering a powerful tool for disease diagnostics. However, the fundamental scale mismatch between optical wavelengths and molecules restricts the application of label-free techniques, leading to poor signal-to-noise (SNR) performance. Here, we propose a high-contrast, label-free approach based on interferometric imaging, utilizing the strong evanescent field supported on a microfiber surface to provide near-field illumination. We observed unique i"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2510.10061","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2510.10061/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}