{"paper":{"title":"Spontaneous polarization for protrusion-driven cell crawling","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.CB"],"primary_cat":"physics.bio-ph","authors_text":"Pierre Recho","submitted_at":"2026-06-09T13:52:09Z","abstract_excerpt":"We propose a minimal one-dimensional continuum model for the spontaneous initiation of protrusion-driven cell crawling on a rigid substrate. The cell cytoskeleton is represented as a viscous actin meshwork that turns over in the bulk and polymerizes at two moving cell edges. Symmetry breaking arises from the feedback between cell motion, an external chemical regulator of actin nucleation, and actin polymerization at the cell fronts. When the cell moves, the regulator becomes polarized around the moving boundaries, thereby imposing different actin nucleation densities at the two edges. This gen"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.10878","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.10878/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}