{"paper":{"title":"Biocompatible Microscale DNA Hydrogels with Programmable Swelling and Sequence-Specific Dissolution","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"A microfluidic platform produces uniform DNA hydrogels that swell up to twice their size and dissolve in response to specific DNA sequences.","cross_cats":[],"primary_cat":"cond-mat.soft","authors_text":"Corinna Torabi, Emily Helm, Harrison Khoo, Rebecca Schulman, Soojung Claire Hur, Sophie Tanenbaum, Takayuki Suzuki","submitted_at":"2026-01-28T16:30:17Z","abstract_excerpt":"Stimulus-responsive DNA-hydrogels with swelling capabilities are a promising class of materials for biomedical applications such as drug delivery and biosensing. However, translation of these systems to microscale applications requires fabrication methods that are both biocompatible and material-efficient, while enabling precise control over stimulus-induced swelling and its impact on molecular transport. Here, we present a biocompatible fabrication and characterization platform for micron-scale DNA-hydrogels (microSDs) with tunable isotropic swelling and dissolving properties. Our approach in"},"claims":{"count":4,"items":[{"kind":"strongest_claim","text":"We present a biocompatible fabrication and characterization platform for micron-scale DNA-hydrogels (microSDs) with tunable isotropic swelling and dissolving properties... achieving up to a two-fold size increase through programmable DNA design parameters.","source":"verdict.strongest_claim","status":"machine_extracted","claim_id":"C1","attestation":"unclaimed"},{"kind":"weakest_assumption","text":"That the microfluidic workflow is truly biocompatible and material-efficient while delivering precise, isotropic swelling without hidden effects from fabrication artifacts or non-specific interactions.","source":"verdict.weakest_assumption","status":"machine_extracted","claim_id":"C2","attestation":"unclaimed"},{"kind":"one_line_summary","text":"Microfluidic fabrication produces monodisperse DNA microgels with programmable isotropic swelling up to twofold and sequence-specific dissolution kinetics controlled by strand displacement and diffusion.","source":"verdict.one_line_summary","status":"machine_extracted","claim_id":"C3","attestation":"unclaimed"},{"kind":"headline","text":"A microfluidic platform produces uniform DNA hydrogels that swell up to twice their size and dissolve in response to specific DNA sequences.","source":"verdict.pith_extraction.headline","status":"machine_extracted","claim_id":"C4","attestation":"unclaimed"}],"snapshot_sha256":"86586403af7ee8159eaf35c8bcdc3d8f181df4c57d0093ead8d5c5e3dfbe6228"},"source":{"id":"2602.00137","kind":"arxiv","version":3},"verdict":{"id":"ff8e9bc9-538b-4a06-8234-60d76231895b","model_set":{"reader":"grok-4.3"},"created_at":"2026-05-16T09:45:11.090775Z","strongest_claim":"We present a biocompatible fabrication and characterization platform for micron-scale DNA-hydrogels (microSDs) with tunable isotropic swelling and dissolving properties... achieving up to a two-fold size increase through programmable DNA design parameters.","one_line_summary":"Microfluidic fabrication produces monodisperse DNA microgels with programmable isotropic swelling up to twofold and sequence-specific dissolution kinetics controlled by strand displacement and diffusion.","pipeline_version":"pith-pipeline@v0.9.0","weakest_assumption":"That the microfluidic workflow is truly biocompatible and material-efficient while delivering precise, isotropic swelling without hidden effects from fabrication artifacts or non-specific interactions.","pith_extraction_headline":"A microfluidic platform produces uniform DNA hydrogels that swell up to twice their size and dissolve in response to specific DNA sequences."},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2602.00137/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":2,"snapshot_sha256":"56adf54141897d15628ae28583f35313d8b9855977bce1659d08b15db733daa7"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}