{"paper":{"title":"Mechanistic bridges from receptors to whole-brain dynamics: mean-field reductions, validity domains, and computational trade-offs","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Alain Destexhe, Lehna Bekri, Yannael Bossard","submitted_at":"2026-07-31T21:38:51Z","abstract_excerpt":"Many pharmacological and pathological mechanisms act at molecular, synaptic, or cellular scales, whereas the resulting phenomena of interest are often measured at the level of cortical populations and whole-brain recordings. This scale gap motivates reduced models that remain biologically interpretable while being tractable enough for whole-brain simulation, parameter exploration, and comparison with empirical signals. This review examines the receptor-aware whole-brain framework of Sacha et al. (2025) as a representative example of such a mechanistic reduction strategy. We reconstruct the mat"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2608.00306","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2608.00306/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}