{"paper":{"title":"Funnel-like protein energy landscapes emerge from functional evolution under thermal fluctuations","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.BM"],"primary_cat":"physics.bio-ph","authors_text":"Macoto Kikuchi, Norifumi Maruyama","submitted_at":"2026-08-02T10:45:18Z","abstract_excerpt":"Proteins perform biological functions by folding into specific native structures that are stabilized by funnel-like energy landscapes shaped through evolution. We investigate whether such foldable proteins can emerge solely from selection for function, without any direct selection for foldability. Using a two-dimensional lattice protein model with four amino-acid types, we define protein function as the equilibrium probability that a prescribed local structure forming an active site is realized at environmental temperature $T$, and use this probability as the evolutionary fitness. Amino-acid s"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2608.01143","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2608.01143/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}