{"paper":{"title":"PRINTER:Deformation-Aware Adversarial Learning for Virtual IHC Staining with In Situ Fidelity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.MM"],"primary_cat":"cs.CV","authors_text":"Bangzheng Pu, Bingsen Xue, Cheng Jin, Chengxiang Wang, Yizhe Yuan","submitted_at":"2025-09-01T07:53:05Z","abstract_excerpt":"Tumor spatial heterogeneity analysis requires precise correlation between Hematoxylin and Eosin H&E morphology and immunohistochemical (IHC) biomarker expression, yet current methods suffer from spatial misalignment in consecutive sections, severely compromising in situ pathological interpretation. In order to obtain a more accurate virtual staining pattern, We propose PRINTER, a weakly-supervised framework that integrates PRototype-drIven content and staiNing patTERn decoupling and deformation-aware adversarial learning strategies designed to accurately learn IHC staining patterns while prese"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2509.01214","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2509.01214/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}