{"paper":{"title":"The heterodimer auto-repression loop: a robust and flexible pulse-generating genetic module","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"B. Lannoo, E. Carlon, M. Lefranc","submitted_at":"2017-05-30T15:17:36Z","abstract_excerpt":"We investigate the dynamics of the heterodimer autorepression loop (HAL), a small genetic module in which a protein A acts as an auto-repressor and binds to a second protein B to form a AB dimer. For suitable values of the rate constants the HAL produces pulses of A alternating with pulses of B. By means of analytical and numerical calculations, we show that the duration of A-pulses is extremely robust against variation of the rate constants while the duration of the B-pulses can be flexibly adjusted. The HAL is thus a minimal genetic module generating robust pulses with tunable duration an in"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1705.10697","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}