{"paper":{"title":"Mapping intratumoral heterogeneity through PET-derived washout and deep learning after proton therapy","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"David Izquierdo-Garc\\'ia, Joaqu\\'in L. Herraiz, Jos\\'e Manuel Ud\\'ias, Luis Mario Fraile, Mailyn P\\'erez-Liva, Pablo Cabrales, V\\'ictor V. Onecha","submitted_at":"2025-06-26T11:23:04Z","abstract_excerpt":"The distribution of produced isotopes during proton therapy can be imaged with Positron Emission Tomography (PET) to verify dose delivery. However, biological washout, driven by tissue-dependent processes such as perfusion and cellular metabolism, reduces PET signal-to-noise ratio (SNR) and limits quantitative analysis. In this work, we propose an uncertainty-aware deep learning framework to improve the estimation of washout parameters in post-proton therapy PET, not only enabling accurate correction for washout effects, but also mapping intratumoral heterogeneity as a surrogate marker of tumo"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.21153","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2506.21153/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}