{"paper":{"title":"Identifying Therapeutic Targets for Triple-Negative Breast Cancer using a Novel Mathematical Model of the Tumor Microenvironment","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Ashley Brown, Helen Moore, Julia Bruner, Kyle Adams, Mohammed Gbadamosi, Salma Ameziane","submitted_at":"2026-01-18T15:30:56Z","abstract_excerpt":"Triple-negative breast cancer (TNBC) is an aggressive disease with high mortality and limited treatment options, due to its lack of receptors that have targeted therapies available. The tumor microenvironment (TME) plays a critical role in TNBC progression and therapeutic resistance. In this work, we developed a novel mathematical model to describe key cellular interactions within the TNBC TME, informed by current literature and expert input. Our model consists of a system of ordinary differential equations representing five interacting cell populations: M2 macrophages, cancer-associated fibro"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2601.12455","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2601.12455/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}