{"paper":{"title":"Global testing of SNP-methylation interactions on binary phenotypes via a logistic functional regression model","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Karim Oualkacha, Lajmi Lakhal-Chaieb, Marzia Angela Cremona, Yvelin Gansou","submitted_at":"2026-07-10T15:40:55Z","abstract_excerpt":"Understanding how genetic and epigenetic factors jointly influence binary health outcomes remains a major challenge in biomedical research. We propose a global test for the overall effect of interactions between DNA methylation and a set of single nucleotide polymorphisms (SNPs) on a binary phenotype. We propose a logistic functional regression model in which methylation measurements at CpG sites are transformed into smooth functional predictors interacting with discrete SNP genotypes through a localized kernel. This framework enables stable inference on region-level interactions while account"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.09535","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2607.09535/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}