{"paper":{"title":"A Fourier-based Approach for Iterative 3D Reconstruction from Cryo-EM Images","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["math.OC","q-bio.BM"],"primary_cat":"math.NA","authors_text":"Amit Singer, Lanhui Wang, Yoel Shkolnisky","submitted_at":"2013-07-22T19:14:08Z","abstract_excerpt":"A major challenge in single particle reconstruction methods using cryo-electron microscopy is to attain a resolution sufficient to interpret fine details in three-dimensional (3D) macromolecular structures. Obtaining high resolution 3D reconstructions is difficult due to unknown orientations and positions of the imaged particles, possible incomplete coverage of the viewing directions, high level of noise in the projection images, and limiting effects of the contrast transfer function of the electron microscope. In this paper, we focus on the 3D reconstruction problem from projection images ass"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1307.5824","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}