{"paper":{"title":"Graphene quantum dots prevent alpha-synucleinopathy in Parkinson's disease","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.mtrl-sci","physics.bio-ph"],"primary_cat":"physics.med-ph","authors_text":"Byung Hee Hong, Donghoon Kim, Han Seok Ko, Heehong Hwang, Je Min Yoo, Junghee Lee, MinJun Lee, Misaki Kinoshita, Myung Jin Park, Saebom Lee, Sang Ho Kwon, Sangjune Kim, Seokmin Shin, Seulah Choi, Seulki Lee, Seung-Hwan Kwon, Seung Pil Yun, Seung R. Paik, Su Hyun Lee, Sung Joong Lee, Yong Joo Park, Young-Ho Lee","submitted_at":"2017-10-17T15:57:59Z","abstract_excerpt":"While the emerging evidence indicates that the pathogenesis of Parkinson's disease (PD) is strongly correlated to the accumulation of alpha-synuclein ({\\alpha}-syn) aggregates, there has been no clinical success in anti-aggregation agents for the disease to date. Here we show that graphene quantum dots (GQDs) exhibit anti-amyloid activity via direct interaction with {\\alpha}-syn. Employing biophysical, biochemical, and cell-based assays as well as molecular dynamics (MD) simulation, we find that GQDs have notable potency in not only inhibiting fibrillization of {\\alpha}-syn but also disaggrega"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1710.07213","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}