{"paper":{"title":"ChromOps.jl: High-order simulation and discrete forward sensitivity analysis for chromatography models","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.NA"],"primary_cat":"math.NA","authors_text":"Christopher Rackauckas, Kristian Meyer, Maksym Ratajczyk","submitted_at":"2026-08-06T15:05:43Z","abstract_excerpt":"Mechanistic chromatography models are valuable for process development, but gradient-based parameter estimation and optimization can be hindered by computational cost and the effort of deriving objective-function gradients. To address this concern, a fully differentiable Julia chromatography solver, ChromOps.jl, is presented that combines high-order spatial discretization with discrete forward sensitivity analysis (DFSA). Two high-order spatial discretizations, finite difference summation-by-parts (FD-SBP) and the discontinuous Galerkin spectral element method (DG-SEM), are compared on a 6-com"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2608.06131","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2608.06131/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}