{"paper":{"title":"Deducing Cardiorespiratory Motion of Cardiac Substructures Using a Novel 5D-MRI Workflow for Radiotherapy","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Carri Glide-Hurst, Chase Ruff, Jiwei Zhao, Kevin Johnson, Oliver Wieben, Prashant Nagpal, Tarun Naren, Thomas Grist","submitted_at":"2025-03-28T16:27:04Z","abstract_excerpt":"Objective: Cardiotoxicity is a devastating complication of thoracic radiotherapy. Current radiotherapy imaging protocols are insufficient to decouple and quantify cardiac motion, limiting substructure-specific motion considerations in treatment planning. We propose a 5D-MRI workflow for substructure-specific motion analysis, with future extension to margin calculation.\n  Approach: Our 5D-MRI workflow was implemented for 10 healthy volunteers, ranging from 23 to 65 years old, reconstructing images for end-exhale/inhale and active-exhale/inhale for end-systole/diastole. For motion assessment, pr"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2503.22578","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2503.22578/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}