{"paper":{"title":"Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.NC","authors_text":"Alex Bersellini Farinotti, Anne-Julie Chabot-Dor\\'e, Azar Baharpoor, Bingze Xu, Birgitta Heyman, Camilla I Svensson, Carlos Morado Urbina, Diana Nascimento, Duygu B Bas, Fredrik Wermeling, Gustaf Wigerblad, Ia Khmaladze, Inna Belfer, Johan Lengqvist, Johanna T Lanner, Jon Sinclair, Juan M. Jimenez-Andrade, Katalin Sandor, Kent Jardemark, Kim Kultima, Kristina \\\"Angeby M\\\"oller, Kutty Selva Nandakumar, Lars E. Borm, Luda Diatchenko, Lu Zhang, Mark S Cragg, Matthew A Hunt, Mattias Collin, Rikard Holmdahl, Sally Abdelmoaty, Simone Codeluppi","submitted_at":"2019-08-08T13:10:21Z","abstract_excerpt":"Rheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomeric matrix protein (COMP), elicit mechanical hypersensitivity in mice, uncoupled from visual, histological and molecular indications of inflammation. Cartilage antibody-induced pain-like behavior does not depend on complement activation or joint inflammation, but instead on tissue antigen recognition and local immune complex (IC) formation. smFISH a"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.05298","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/1908.05298/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}