{"paper":{"title":"Sensitivity analysis of a computational model of the IKK-NF-{\\kappa}B-I{\\kappa}B{\\alpha}-A20 signal transduction network","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN","q-bio.SC"],"primary_cat":"q-bio.QM","authors_text":"Jaewook Joo, Jean-Loup Faulon, Laura Swiler, Shawn Martin, Steve Plimpton","submitted_at":"2010-10-08T18:21:45Z","abstract_excerpt":"The NF-{\\kappa}B signaling network plays an important role in many different compartments of the immune system during immune activation. Using a computational model of the NF-{\\kappa}B signaling network involving two negative regulators, I{\\kappa}B{\\alpha} and A20, we performed sensitivity analyses with three different sampling methods and present a ranking of the kinetic rate variables by the strength of their influence on the NF-{\\kappa}B signaling response. We also present a classification of temporal response profiles of nuclear NF-{\\kappa}B concentration into six clusters, which can be re"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1010.1755","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}