{"paper":{"title":"Beyond the Composite: Enhancing Trial Analysis through a Divide & Conquer Approach to 'Days Alive and at Home': Insights from the NOTACS trial","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["stat.AP"],"primary_cat":"stat.ME","authors_text":"Dominique-Laurent Couturier, Letao Yuan, Sof\\'ia S. Villar","submitted_at":"2026-05-15T20:14:17Z","abstract_excerpt":"\"Days alive and at home\" (DAH) is a recent patient-centered outcome measure for perioperative trials, defined as the number of days a patient spends at home during the follow-up period. DAH typically follows a zero-inflated, left-skewed, bi-modal distribution. Other increasingly used complex endpoints, such as days alive without a ventilator, share these statistical features arising from combining survival with another clinically relevant count outcome into a single, comprehensive measure. A key challenge for DAH and similar endpoints is the lack of a readily identifiable distributional form, "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2605.16606","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2605.16606/integrity.json","findings":[],"available":true,"detectors_run":[{"name":"claim_evidence","ran_at":"2026-05-19T19:21:56.803130Z","status":"completed","version":"1.0.0","findings_count":0},{"name":"ai_meta_artifact","ran_at":"2026-05-19T18:33:26.597602Z","status":"skipped","version":"1.0.0","findings_count":0}],"snapshot_sha256":"6cdf7ca7126afcf298339dcf181c0e7ab746b1d9ef2ced2ae65d0a556db450c1"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}