{"paper":{"title":"Mathematical analysis and potential therapeutic implications of a novel HIV-1 model of basal and activated transcription in T-cells and macrophages","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.PE","authors_text":"Catherine DeMarino, Daniel M. Anderson, Fatah Kashanchi, Maria Emelianenko, Tin Phan, Yang Kuang","submitted_at":"2020-05-22T18:23:20Z","abstract_excerpt":"HIV-1 affects tens of millions of people worldwide. Current treatments often involve a cocktail of antiretroviral drugs, which are effective in reducing the virus and extending life spans. However, there is currently no FDA-approved HIV-1 transcription inhibitor. Furthermore, there have only been a few attempts to model the transcription process in HIV-1. In this work, we extend a novel three-state model of HIV-1 transcription introduced in DeMarino et al. (2020) that has been developed and validated against experimental data. After fitting this model to in vitro data, significant differences "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2005.11343","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2005.11343/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}