{"paper":{"title":"Decoding the Alzheimer's Continuum: Interpretable Multi-Gate Routing for Diagnosis and Transition Prediction","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"eess.IV","authors_text":"Gerald W.Y. Cheng, Haoran Xie, Hexiao Ding, Hongzhao Chen, Jing Cai, Jing Lan, Jung Sun Yoo, Xinzhi Teng, Yufeng Jiang, Yunlin Mao, Zongxi Li","submitted_at":"2025-08-03T16:15:49Z","abstract_excerpt":"Alzheimer's disease (AD) manifests as a continuous progression from normal cognition (NC) through mild cognitive impairment (MCI) to dementia. However, most deep learning approaches reduce this continuum to disjointed classification tasks, largely ignoring dynamic stage transitions. To decode this complex progression, we propose M$^3$AD, a unified framework that jointly addresses three-class diagnosis classification and diagnosis stage transition prediction using only T1-weighted sMRI. M$^3$AD leverages an interpretable multi-gate mixture of experts architecture, employing specialized routing "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.01819","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2508.01819/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}