{"paper":{"title":"Hamiltonian Dynamics and Fundamental Phenomena in Biophysics: A Review","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"Giulio Pettini, Marco Pettini, Matteo Gori, Roberto Franzosi","submitted_at":"2026-07-03T19:20:24Z","abstract_excerpt":"We review a theoretical and experimental programme addressing two closely related phenomena in biophysics: the classical analogue of Fr\\\"ohlich phonon condensation in macromolecules driven out of thermal equilibrium, and the resulting activation of long-range resonant electrodynamic intermolecular forces.The first is obtained by applying the time-dependent variational principle (TDVP) to the quantum Wu-Austin model,yielding a fully classical Hamiltonian in action-angle variables whose nonlinear rate equations display a nonequilibrium phase transition: supplied energy is channelled into the low"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.20508","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2607.20508/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}