{"paper":{"title":"Hierarchical cell identities emerge from animal gene regulatory mechanisms","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"q-bio.CB","authors_text":"Abhirup Mukherjee, Anton Grishechkin, Omer Karin","submitted_at":"2024-12-15T23:04:07Z","abstract_excerpt":"The hierarchical organisation of cell identity is a fundamental feature of animal development with rich and well-characterized experimental phenomenology, yet the mechanisms driving its emergence remain unknown. The regulation of cell identity genes relies on a distinct mechanism involving higher-order interactions of transcription factors on distant regulatory regions called enhancers. These interactions are mediated by epigenetic regulators that are broadly shared between enhancers. Through the development of a new and predictive mathematical theory on the effects of epigenetic regulator act"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2412.11336","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2412.11336/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}