{"paper":{"title":"Towards model-based design of causal manipulations of brain circuits with high spatiotemporal precision","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Anandita De, Luca Mazzucato, Roozbeh Kiani","submitted_at":"2025-05-30T16:52:44Z","abstract_excerpt":"Recent advancements in neurotechnology enable precise spatiotemporal patterns of microstimulations with single-cell resolution. The choice of perturbation sites must satisfy two key criteria: efficacy in evoking significant responses and selectivity for the desired target effects. This choice is currently based on laborious trial-and-error procedures, unfeasible for sequences of multi-site stimulations. Efficient methods to design complex perturbation patterns are urgently needed. Can we design a spatiotemporal pattern of stimulation to steer neural activity and behavior towards a desired targ"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.24790","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.24790/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}