{"paper":{"title":"Correlates of severity of disease in Macaca mulatta infected with Plasmodium cynomolgi","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.TO","authors_text":"Diego M. Moncada, Elizabeth D. Trippe, Juan B. Gutierrez, Yi H. Yan","submitted_at":"2017-06-25T16:19:18Z","abstract_excerpt":"Characterization of host responses associated with severe malaria through an integrative approach is necessary to understand the dynamics of a \\textit{Plasmodium cynomolgi} infection. In this study, we conducted temporal immune profiling, cytokine profiling and transcriptomic analysis of five \\textit{Macaca mulatta} infected with \\textit{P. cynomolgi}. This experiment resulted in two severe infections, and two mild infections. Our analysis reveals that differential transcriptional up-regulation of genes linked with response to pathogen-associated molecular pattern (PAMP) and pro-inflammatory c"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1706.08836","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}