{"paper":{"title":"Which Regularized Propensity-Score and Doubly Robust Methods Are Best Calibrated When Exposures or Outcomes Are Rare? A Plasmode Study of Proxy-Based Confounding Adjustment","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.CO","stat.ME"],"primary_cat":"stat.AP","authors_text":"M. Ehsan Karim, Wanqing Hu","submitted_at":"2026-07-08T06:48:07Z","abstract_excerpt":"Purpose. Confounding adjustment in health-care database studies screens large proxy libraries where events per variable are low, straining standard propensity score (PS) methods, and many regularized variable-selection strategies exist (outcome-adaptive LASSO [OAL], group LASSO/GLiDeR, highly adaptive LASSO [HAL]). Yet few comparisons have varied exposure prevalence within such a selection menu, and none pairs it with doubly robust estimation, compute accounting, and a null-RD truth anchor.\n  Methods. We conducted a plasmode simulation anchored on National Health and Nutrition Examination Surv"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.07065","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2607.07065/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}