{"paper":{"title":"Improving Richardson--Lucy Deconvolution with Diffusion Priors for Fluorescence Microscopy","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["physics.optics"],"primary_cat":"eess.IV","authors_text":"Hao Chen, Scott S. Howard","submitted_at":"2026-06-24T15:03:35Z","abstract_excerpt":"Richardson--Lucy (RL) deconvolution improves fluorescence microscopy images by recovering details lost to diffraction. It estimates the original fluorescence signal that most likely produced the measured photon counts under a Poisson imaging model. Although RL incorporates a physical model of fluorescence image formation and can improve contrast, deconvolution remains fundamentally ill-posed, and the measurements alone provide limited evidence for reliably reconstructing fine biological structure. Without additional structural guidance, RL can amplify noise and exhibit unstable convergence in "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.25924","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.25924/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}