{"paper":{"title":"Refining Platelet Purification Methods: Enhancing Proteomics for Clinical Applications","license":"http://creativecommons.org/publicdomain/zero/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.BM","authors_text":"Dorota Goplen, Einar K. Kristoffersen, Frode Selheim, Katarina Fritz-Wallace, Olav Mjaavatten, Vibecke Markhus","submitted_at":"2025-05-30T09:24:18Z","abstract_excerpt":"Background: Platelet proteomics offers valuable insights for clinical research, yet isolating high-purity platelets remains a challenge. Current methods often lead to contamination or platelet loss, compromising data quality and reproducibility.\n  Objectives: This study aimed to optimize a platelet isolation technique that yields high-purity samples with minimal loss and to identify the most effective mass spectrometry-based proteomic method for analyzing platelet proteins with optimal coverage and sensitivity.\n  Methods: We refined an isolation protocol by adjusting centrifugation time to red"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.24394","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.24394/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}