{"paper":{"title":"Relevance of intracellular polarity to accuracy of eukaryotic chemotaxis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.CB","authors_text":"Akihiro Nagamatsu, Masatoshi Nishikawa, Naohiro Akuzawa, Tatsuo Shibata, Tetsuya Hiraiwa","submitted_at":"2013-08-07T09:23:47Z","abstract_excerpt":"Chemotactic cells establish cell polarity in the absence of external guidance cues. Such self-organized polarity is induced by spontaneous symmetry breaking in the intracellular activities, which produces an emergent memory effect associated with slow-changing mode. Therefore, spontaneously established polarity should play a pivotal role in efficient chemotaxis. In this study, we develop a model of chemotactic cell migration that demonstrates the connection between intracellular polarity and chemotactic accuracy. Spontaneous polarity formation and gradient sensing are described by a stochastic"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1308.1514","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}