{"paper":{"title":"Using stochastic thermodynamics with internal variables to capture orientational spreading in cell populations undergoing cyclic stretch","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.soft","math-ph","math.MP","math.PR"],"primary_cat":"cond-mat.stat-mech","authors_text":"Giuseppe Saccomandi, Giuseppe Tomassetti, Rohan Abeyaratne, Sanjay Dharmaravan","submitted_at":"2025-07-21T15:05:30Z","abstract_excerpt":"We revisit the modeling framework introduced in [N. Loy and L. Preziosi: Bull. Math. Bio., 85, 2023] to describe the dynamics of cell orientation under cyclic stretch. We propose a reformulation based on the principles of Stochastic Thermodynamics with Internal Variables introduced in [T. Leadbetter, P. Purohit, and C. Reina: PNAS Nexus, 2, 2023]. This approach allows us to describe not only the evolution of the orientation distribution, but also the observed spreading phenomenon. The insight provided by our model reveals an interesting phenomenon, which we call two-stage reorientation: when c"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2507.15694","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2507.15694/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}