{"paper":{"title":"Resistance Management for Cancer: Lessons from Farmers","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Alexander May, Amy M. Boddy, Carlo C. Maley, Christina Wu, Daniel Saha, Dawn H. Gouge, Efe Fakir, Lida Mina, Luis Cisneros, Marco Gerlinger, Peter C. Ellsworth, Rezvan Yousefi, Sareh Seyedi, Silvie Huijben, Stefania E. Kapsetaki, Valerie K. Harris, Zachary Compton","submitted_at":"2023-04-01T22:52:53Z","abstract_excerpt":"One of the main reasons we have not been able to cure cancers is that drugs select for drug-resistant cancer cells. Pest managers face similar challenges with pesticides selecting for pesticide-resistant organisms. Lessons in pest management have led to four heuristics that can be translated to controlling cancers 1. limit use (of chemical controls or modes of action to the lowest practical levels) 2. diversify use (of modes of action largely through rotations of chemical controls) 3. partition chemistry (modes of action through space and time, which in effect is a refuge management strategy) "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2304.00402","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2304.00402/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}