{"paper":{"title":"Analytical and empirical measurement of fiber photometry signal volume in brain tissue","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.NC"],"primary_cat":"physics.optics","authors_text":"Antonio Balena, Bernardo L Sabatini, Emanuela Maglie, Ferruccio Pisanello, Filippo Pisano, Marco Pisanello, Massimo De Vittorio, Minsuk Hyun","submitted_at":"2018-07-09T10:17:34Z","abstract_excerpt":"Fiber photometry permits monitoring fluorescent indicators of neural activity in behaving animals. Optical fibers are typically used to excite and collect fluorescence from genetically-encoded calcium indicators expressed by a subset of neurons in a circuit of interest. However, a quantitative understanding of the brain volumes from which signal is collected and how this depends on the properties of the optical fibers are lacking. Here we analytically model and experimentally measure the light emission and collection fields for optical fibers in solution and scattering tissue, providing a comp"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1807.03023","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}