{"paper":{"title":"Sensitivity of ECG QRS Complexes to His-Purkinje Structure in Computational Heart Models","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.OT"],"primary_cat":"q-bio.QM","authors_text":"Annie Green Howard, Boyce E. Griffith, Karin Leiderman, Laryssa Abdala, Preetam V. Tanikella","submitted_at":"2025-05-22T14:00:05Z","abstract_excerpt":"Cardiac digital twins (CDT) are emerging as a potentially transformative tool in cardiology. A critical yet understudied determinant of CDT accuracy is the His-Purkinje system (HPS), which influences ventricular depolarization and shapes the QRS complex of the electrocardiogram (ECG). Here, we quantify how structural variations in the HPS alter QRS morphology and identify which parameters drive this variability. We generated HPS structures using a fractal-tree, rule-based algorithm, systematically varying nine model parameters and assessing their effects on ten QRS-related metrics. We conducte"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.16696","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.16696/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}