{"paper":{"title":"Empirical prior distributions for treatment-by-subgroup interaction heterogeneity in random-effects meta-analysis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Christian R\\\"over, Renato Panaro, Tim Friede","submitted_at":"2026-06-22T21:47:33Z","abstract_excerpt":"Subgroup analyses are central to the assessment of benefits and risks, where recommendations may depend on evidence that treatment effects differ across patient groups. Valid subgroup claims require evidence based on (within-trial) interaction estimates while accounting for the heterogeneity in those interaction effects. In the common case of only a few available studies, inference may benefit from the use of prior information on the expected amount of heterogeneity. Although between-study heterogeneity~($\\tau$) has been studied empirically for overall treatment effects, no such calibration ex"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.23968","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.23968/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}