{"paper":{"title":"Thermally Robust Cooperative Function in Mechanical Networks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"cond-mat.soft","authors_text":"Andrea J. Liu, Ben Pisanty, Jovana A. Kim, Sidney R. Nagel","submitted_at":"2025-09-24T20:55:25Z","abstract_excerpt":"Elastic networks can be tuned to exhibit complex mechanical responses and have been extensively used to study protein allostery, where a localized strain regulates the conformation at a distant site. We show that cooperative binding, where one site enhances the other's ability to function, can be improved by tuning for \\textit{bidirectional} allostery: a symmetric coupling where the strain propagated between the two sites is independent of which site is perturbed. We identify a crossover temperature above which functionality breaks down due to thermal fluctuations. We introduce a modified tuni"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2509.20560","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2509.20560/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}