{"paper":{"title":"Prob-cGAN: A Probabilistic Conditional Generative Adversarial Network for LSD1 Inhibitor Activity Prediction","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"cs.CE","authors_text":"Hanyang Wang","submitted_at":"2024-11-23T07:48:59Z","abstract_excerpt":"The inhibition of Lysine-Specific Histone Demethylase 1 (LSD1) is a promising strategy for cancer treatment and targeting epigenetic mechanisms. This paper introduces a Probabilistic Conditional Generative Adversarial Network (Prob-cGAN), designed to predict the activity of LSD1 inhibitors. The Prob-cGAN was evaluated against state-of-the-art models using the ChEMBL database, demonstrating superior performance. Specifically, it achieved a top-1 $R^2$ of 0.739, significantly outperforming the Smiles-Transformer model at 0.591 and the baseline cGAN at 0.488. Furthermore, it recorded a lower $RMS"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.15483","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2411.15483/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}