{"paper":{"title":"Tensile Forces and Shape Entropy Explain Observed Crista Structure in Mitochondria","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.SC"],"primary_cat":"cond-mat.soft","authors_text":"A. Rabinovitch, A.R.C. Baljon, J. D. Nulton, M. Ghochani, P. Salamon, T. G. Frey","submitted_at":"2010-04-03T23:56:02Z","abstract_excerpt":"A model is presented from which the observed morphology of the inner mitochondrial membrane can be inferred as minimizing the system's free energy. Besides the usual energetic terms for bending, surface area, and pressure difference, our free energy includes terms for tension that we believe to be exerted by proteins and for an entropic contribution due to many dimensions worth of shapes available at a given energy.\n In order to test the model, we measured the structural features of mitochondria in HeLa cells and mouse embryonic fibroblasts using 3D electron tomography.  Such tomograms reveal "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1004.0473","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}