{"paper":{"title":"Effects of macromolecular crowding on the collapse of biopolymers","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.BM"],"primary_cat":"cond-mat.soft","authors_text":"Changbong Hyeon, D. Thirumalai, Hongsuk Kang, Philip A. Pincus","submitted_at":"2014-09-19T14:04:35Z","abstract_excerpt":"Experiments show that macromolecular crowding modestly reduces the size of intrinsically disordered proteins (IDPs) even at volume fraction ($\\phi$) similar to that in the cytosol whereas DNA undergoes a coil-to-globule transition at very small $\\phi$. We show using a combination of scaling arguments and simulations that the polymer size $\\overline{R}_g(\\phi)$ depends on $x = \\overline{R}_g(0)/D$ where $D$ is the $\\phi$-dependent distance between the crowders. If $x\\lesssim \\mathcal{O}(1)$, there is only a small decrease in $\\overline{R}_g(\\phi)$ as $\\phi$ increases. When $x\\gg \\mathcal{O}(1)$"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1409.5663","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}