{"paper":{"title":"A Comprehensive Toolbox to Facilitate Quantitative Decision Science in Drug Development: A web-based R shiny application GOahead","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":[],"primary_cat":"stat.AP","authors_text":"Alan Chiang, Alan Wu, Bo Wei, Michael Branson, Nanxiang Ge, Rong Liu, Weibin Zhong","submitted_at":"2022-01-27T01:43:23Z","abstract_excerpt":"Decision-making is critical at each stage of drug development and making informed and transparent Go/No-Go decisions require a sound quantitative decision framework. We designed and implemented GOahead, a comprehensive web-based tool to improve how statisticians and collaborators could prospectively plan and implement the selected Go/No-Go decision approach in real-time. In the paper, we conducted a comprehensive overview of dual-criterion and confidence interval-based approaches to enable quantitative decision-making. illustrative examples are demonstrated for single and two arms designs in b"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2201.11267","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2201.11267/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}