{"paper":{"title":"Excess area dependent scaling behavior of nano-sized membrane tethers","license":"http://creativecommons.org/publicdomain/zero/1.0/","headline":"","cross_cats":["cond-mat.mes-hall","cond-mat.soft","cond-mat.stat-mech","physics.comp-ph"],"primary_cat":"physics.bio-ph","authors_text":"Arpita Roychoudhury, David M. Eckmann, N. Ramakrishnan, Portnovo S. Ayyaswamy, Ravi Radhakrishnan, Shivprasad Patil, Thomas Pucadyil, Tobias Baumgart, Valerie M. Weaver","submitted_at":"2016-10-22T22:42:14Z","abstract_excerpt":"Thermal fluctuations in cell membranes manifest as an excess area (${\\cal A}_{\\rm ex}$) which governs a multitude of physical process at the sub-micron scale. We present a theoretical framework, based on an in silico tether pulling method, which may be used to reliably estimate ${\\cal A}_{\\rm ex}$ in live cells. The tether forces estimated from our simulations compare well with our experimental measurements for tethers extracted from ruptured GUVs and HeLa cells. We demonstrate the significance and validity of our method by showing that all our calculations along with experiments of tether ext"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1610.07099","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}