{"paper":{"title":"Uncertainty of high-dimensional genetic data prediction with polygenic risk scores","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["math.ST","stat.TH"],"primary_cat":"stat.ME","authors_text":"Bingxin Zhao, Haoxuan Fu, Jiaoyang Huang, Zirui Fan","submitted_at":"2024-12-29T22:59:09Z","abstract_excerpt":"In many predictive tasks, there are a large number of true predictors with weak signals, leading to substantial uncertainties in prediction outcomes. The polygenic risk score (PRS) is an example of such a scenario, where many genetic variants are used as predictors for complex traits, each contributing only a small amount of information. Although PRS has been a standard tool in genetic predictions, its uncertainty remains largely unexplored. In this paper, we aim to establish the asymptotic normality of PRS in high-dimensional predictions without sparsity constraints. We investigate the popula"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2412.20611","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2412.20611/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}